Artificial Heart Program (AHP)


Promote bio-engineering research in Engineering Institutes of India in collaboration with Medical Institutions, Engineering Industries and Medical device developers to develop medical devices in India.


Moon-shot: Develop total artificial heart

Immediate: Development of Left Ventricular Assist Device (LVAD) / (ECMO) Extracorporeal Membrane Oxygenator

Key Activities:

The LVAD has two critical parts, Motor and Pump Head. It can be used as LVAD and ECMO with addition of oxygenator in the circuit.

The project is developing LVAD / ECMO Blood Pump. SHARE INDIA jump started its activities toward the development of a blood pump suitable for bench testing and pre-clinical readiness.

The disposable pump head is being developed by CBIT, KITS and SNIST. The 3D printed prototype underwent In-Vitro testing in AIG hospital using a mockloop testing system developed by our team. (Figure 1). Its showed minimal hemolysis comparable to similar devices in extensive use. Therefore, it is given for injection molding.

The motor is being developed by Laxven Systems, the motor works on Maglev principle, which levitates and rotates the impeller which is inside the pump without any physical contact. (Figure 2).

Simultaneously control studies are being performed with existing LVAD/ ECMO devices on sheep at Palamur Bioscience Labs. ( image). Testing for von Willebrand factor accrued deficiency is being developed by BITS Pilani, Hyderabad Campus.


SHARE INDIA, Hyderabad, India

  • Dr. P. S. Reddy, Chairman
  • Dr. Vijay V. Yeldandi, Head Infectious Diseases and Public Health
  • Dr. Shikha Dhawan, Director Programs
  • Dr. B. M. Gandhi, Chief Executive Officer, Neo BioMed Services, New Delhi
  • Dr. A. G. K. Gokhale, Cardiothoracic Surgeon, Apollo Hospitals, Hyderabad

Birla Institute of Technology (BITS) PILANI, Hyderabad, India

  • Dr. Suman Kapur, Senior Professor, Department of Biological Sciences

Kakatiya Institute of Technology & Science, (KITS) Warangal, India

  • Dr. K. Ashoka Reddy, Principal
  • Dr. K. Sridhar, Professor & Head of Mechanical Engineering
  • Dr. Venu Madhav Kotturu, Professor of Electronics & Instrumentation Engineering
  • Dr. Ganesh Kumar Gampa, Associate Professor, Dept of Mechanical Engineering
  • Dr. Sai Kumar Gadakary, Asst Professor, Dept. of Mechanical Engineering

Sreenidhi Institute of Science and Technology (SNIST), Hyderabad.

  • Ms. Sadia Alvi, Asst Professor, Dept. of Mechanical Engineering

Asian Institute of Gastroenterology (AIG), Hyderabad, India

  • Dr. P. Naveen Chander Reddy, Medical Director
  • Dr. C. Sukesh Kumar Reddy, Sr. Consultant Cardiothoracic Surgeon
  • Dr. Naresh Kumar, Cardiothoracic Surgeon
  • Dr. Rajeev Vijay Kumar Menon, Sr. Consultant - lnterventional Cardiology
  • Dr. Sachin Yalagudri, Sr. Consultant Cardiologist and Electrophysiologist

Laxven Industries, Hyderabad, India

  • Mr. C. Ramesh Reddy, Managing Director; Electromechanical Manufacturing

Shristi Resins Hyderabad, India

  • Mr. K. P. Reddy, Managing Director

Palamur Biosciences Pvt. Ltd., Mahbubnagar, India

  • Mr. K. Venkata Reddy, Managing Director
  • Mr. T. Vijayaragavan, Chairman
  • Dr. Rammoorthy, Test Facility Management
  • Dr. D. C. Sharma, Medical Research Institute for Device Assessment (MRIDA)
  • Dr. S. Anoop, Medical Research Institute for Device Assessment (MRIDA)

Shree Pacetronix Ltd., Indore, India

  • Mr. Atul Sethi, Executive Director & Managing Director
  • Mr. Aakash Sethi, Executive Director & Joint Managing Director
  • Mr. Vikas Gokhale, Technical Director-Research

We gratefully acknowledge critical voluntary help being provided by the following international experts from the inception of the project:

  • Prof. Harvey Borovetz, Professor of Bioengineering, University of Pittsburgh, USA
  • Dr. Shawn Bengston, Director of Quality Management Systems, University of Pittsburgh, USA
  • Dr. Joe Hanke, Surgery Supervisor, McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA
  • Dr. William R. Wagner, Director of the McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA
  • Dr. Edward Klein, Director of Pathology Services at Division of Laboratory Animal Resources, Faculty from University of Pittsburgh, USA
  • Prof. James Antaki, Professor of Heart Assist Technology, Cornell Engineering, Cornell University, Ithaca, New York, USA
  • Dr. James Long, Cardio thoracic surgeon, Medical Director, Nazih Zuhdi Transplant Institute - INTEGRIS Baptist Medical Center, Oklahoma, USA
  • Dr. Kurt Dasse, Co-Founder, President & CEO, Inspired Therapeutics, Florida, USA
  • Dr. Barry Gellman, Chief Technology Officer, Inspired Therapeutics, Florida, USA
  • Ms. Priscilla Petit, Co-Founder, Director of Quality & Regulatory, Inspired Therapeutics, Florida, USA
  • Dr. Tim Kaufmann, Chief Executive Officer, enmodes GmbH, Aschen, Germany
  • Dr. Deepanshu Sodhani, R&D Project Manager, enmodes GmbH, Aschen, Germany

Figure 1 Mock Loop Setup at AIG Hospital

Figure 2 Motor and Controller - LAXVEN engineering

Design of the Blood Pumps

  • A Internal Jugular vein cannula
  • B Pre-pump line
  • C Straight connector with luer lock
  • D Centrifugal pump- Centrimag Blood pump
  • E Post pump line
  • F Pre-membrane pressure monitoring/ sample Hport
  • G Membrane oxygenator
  • H Gas blender
  • I Post oxygenator line
  • J Post membrane pressure monitoring/ sample Mport
  • K Carotid artery cannula (Return cannula)
  • L Flow probe
  • L Flow meter

The study teams at Palamur Bio Sciences, Mahabubnagar, Telangana and on Zoom e-meeting during sheep studies

  • An Abstract title “PEDS6: Virtual Anatomic Fit Study of PediaFlow Implantable VAD in Infants (4 Kg To 8 Kg)” Been selected for the Oral presentation for the ASAIO 2022 International Conference, Chicago, USA.
  • An Abstract title “Fast and Effective Method to Conduct Flow Visualization of Blood Pump” Been selected for the poster presentation for the ASAIO 2020 International Conference, Chicago, USA
  • Rugveda T, Sadia Alvi, Dr Ravinder Reddy., Design of Mock Circulatory Test Loop with LV Simulator for a Centrifugal Blood Pump, ASAIO 2020 Dr Ravinder Reddy., Rugveda T., Chemical Polishing Method to Improve the Surface Roughness of FDM Printed Component of Blood Wetted Devices, ASAIO 2020
  • Ganesh Kumar, G., Ashoka Reddy, K., Venu Madhav K., Eswaraiah. K., Experimental and Numerical Studies of a Centrifugal Heart Pump Used for Total Artificial Heart (TAH), ASAIO 2021
  • Ganesh Kumar, G., Ashoka Reddy, K., Venu Madhav K., Eswaraiah. K., Comparative Studies on six and four bladed Centrifugal Heart Pump Used for Left Ventricular Assisted Device (LVAD),ASAIO 2021
  • Ganesh Kumar, G., Ashoka Reddy, K., Venu Madhav K., Eswaraiah. K., (2020), "Mathematical and Experimental Studies on Effect Of Number Of Blades On Centrifugal Pump Used In Left Ventricular Assisted Device (LVAD), ASAIO Journal June 20, Volume 66, ISSN 1058-2916, pp 83, (DOI: l 0.1097/MAT.0000000000001l 86), Wolters Kluwer Publishers